Main ongoing projects

  • EIT Health project PAPHOS: Platform for advanced prescriptive health operational system
    • Big data in healthcare (use cases: digital pathology & sleep apnea)
    • Granted by the European Institute of Innovation & Technology / Knowledge and Innovation Community (KIC) - EIT Health
    • Consortium: ATHOS Spain SAE, BULL SAS, CEA, Univ. Pierre et Marie Curie - Paris 6 (UPMC), Univ. Joseph Fourier (UJF), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Universidad Politécnica de Madrid, GMV soluciones globales internet (GMV), Karolinska Instituet (KI), AVENTYN.
    • URL EIT Health: http://eit.europa.eu/eit-community/eit-health
    • URL PAPHOS: https://www.eithealth.eu/paphos
    • Personal role in PAPHOS: Digital Pathology use-case with the Pitié-Salpêtrière Hospital, Paris.
    • Duration: Two years year (2016-2017).

  • Multiparametric ultrasonic classification to evaluate tumor progression
    • Granted by the Medical Research Foundation (FRM, France); Bio-ingénieering for health
    • Partners: Sorbonne Universités, Hopital de la Pitié-Salpêtrière, Biacoustics Research Lab / Univ.Illinois Urbana-Champaign
    • Duration: 3 years (2014–2017)

  • Quantitative Tumour Angiogenesis Assessments using 3D Radiographic/ Histopathologic Imaging and Xenotransplantation for Cancer Therapy
    • Granted by Career Development Award (CDA A*STAR / JCO)
    • Partners: Bioinformatics Institute, National Cancer Centre Singapore, Singapore General Hospital, Institute for Infocomm Research, Roche Translational Medicine Hub – Singapore, Inst. Bioengineering & Nanotech, Nanyang Technological University
    • Duration: 3 years (2014–2017)

Major previous projects

  • IAMS – A suite of integrated autonomous microscopy systems for imaging anatomies of complex 3D cell culture systems
    • Project funded by A*STAR/JCO (Joint Council SERC-BMRC/A*STAR) Singapore
    • Partners: three A*STAR institutes (the Institute for Infocomm Research I2R/SERC, the Bioinformatic Institute BII/BMRC, the Institute of Molecular and Cell Biology IMCB/BMRC and the Institute of Medical Biology IMB/BMRC)
    • Duration: 3 years (2013–2016)

  • FlexMIm – collaborative digital histopathology
    • Funded by the Consolidated Interministerial Fund (Fonds Unitaires Interministériels) French Ministry of Industry (MINEFE)
    • Project involving Orange Heathcare, Tribvn, Pertimm, the University Pierre and Marie Curie, the Univ. Paris Diderot and the Assistance publique – Hôpitaux de Paris, the public hospital system (établissement public de santé) of the city of Paris and its suburbs (AP-HP).
    • Role: Co-Principal Investigator and WP manager (Semantic and Imaging)
    • Duration: 3.5 years (2013–2016)

  • MICO - COgnitive MIcroscope: A cognition-driven visual explorer for histopathology. Application to breast cancer grading.
    • Granted by the Technologies for Health program (TecSan - Technolgies pour la Sante) of the French National Research Agency (Agence Nationale de la Recherche - ANR).
    • Partners: IPAL/UJF, LIP6/UPMC, TRIBVN (SME Châtillon/Paris), THALES-TCF,  Pitié-Salpêtrière Hospital - Paris, AGFA Healthcare France
    • Personal role in the project: Principal Investigator,
    • Duration: 3.5 years (2011–2014)
    • Objectives:
      • The cognitive microscope (MICO) aims at radically modifying the medical practices by proposing a new cognitive medical imaging environment able to improve reliability of decision making in histopathology.
      • MICO aims at moving a step forward in medical practice by proposing the foundations of a new confluent cognitive medical imaging technology using context in intelligent way.
      • MICO behaves in a cognitively consistent way with standard medical practice, following a uniform representation of image analysis, reasoning and context elements.
    • Deliverables, reports

  • IVS4NSC - "An Intelligent Vision System for Quantitative Microscopy in Neural Stem Cells Progenitor Growth and Differentiation"
    • Granted by A*STAR/JCO (Joint Council Office, A*STAR) Singapore
    • Partners: The project involves IPAL and three A*STAR institutes (Institute for Infocomm Research I2R/SERC, Bioinformatic Institute BII/BMRC and the Institute of Medical Biology IMB/BMRC)
    • Duration: 3,5 years (2009–2013)
    • Objectives:
      • The project aims to develop an intelligent vision system for the analysis of neural stem cells, their progenitors and cell differentiation; by integrating image processing and machine learning with microscopy to drive systematic high-throughput high-content screening to elucidate gene functions and signalling pathways.
      • The vital knowledge gained in this project can potentially be applied as therapeutics for the treatment of Central Nervous System diseases such as Parkinson's and Alzheimer's.
    • Related link: Image Informatics of Stem Cells
  • IC0604 - EURO-TELEPATH -“Telepathology Network in Europe”
    • COST Action European Cooperation in Science and Technology
    • Partners: Spain, France, Germany, Grece, Italy, Switzerland, Croatia, Finland, Lithuania, Nederland, Norway, Poland, Portugal, United Kingdom.
    • Duration: 4 years (2007–2011)
    • Domain : telepathology, virtual microscopy, histopathology

  • MMedWeb "Multimedia Medical Conceptual Web for Intelligent Information Access"
    • Granted by A*STAR/SERC - Science & Engineering Research Council, Agency for Science, Technology and Research, Singapore
    • Partners: CNRS, NUS, I2R/A*STAR, Nat. Univ. Hospital (NUH), National Healthcare Group, Singapore General Hospital (SGH)
    • Personal role in the project; Co-Principal Investigator
    • Duration: 3 years (2007–2010)
    • Objectives:
      • Developing a framework for the semantic structuring and organization of multimedia medical information (images, reports).
      • Implementing a prototype system of the framework with user-friendly network tools for navigation and query of MMedWeb.
      • Trial integration of MMedWeb with existing medical databases (PACS, RIS, etc.)
    • MMedWeb Project assessment (2010) [slides]

  • ONCO-MEDIA "Ontology and COntext related MEdical image Distributed Intelligent Access"
    • Funded by the 5th ICT-ASIA Programme (France / Asia)
    • International partners from Singapore (IPAL), France (CREATIS, LIRIS, LIP6, IS3, FEMTO-ST), Switzerland (UNIGE), Taiwan (NTU), Philippine (ATENEO), Japan (CIGG)
    • Personal role in the project: Principal Investigator
    • Duration: 2 years (2006–2007 and 2009–2010)
    • Objectives:
      • To develop a novel grid-distributed, contextual and semantic based, intelligent information access framework for medical images and associated medical reports
      • To explore new medical image diagnosis assistance, teaching and research access applications using semantic, visual and context-sensitive medical information with the grid computing facilities
      • To crystallize a network of research excellence in the field of distributed medical images access among Asia, French and French Switzerland partners, leveraging on their complementary scientific values and experience
    • ONCO-MEDIA Project assessment (2010) [pdf]

  • PROTEUS - A Generic Platform for E-maintenance
    • FP5 European Integrated Project of ITEA program (Information Technology for European Advancement)
    • Duration : 3 years (2002–2005)
    • 14 European industrial and academic partners (France; Germany, Belgium) : CEGELEC, AKN, Univ. Munich, LORIA-INRIA/CNRS, LIP6/UPMC, FEMTO-ST/UFC, LIFC/UFC, Pertinence Data ...

  • NEMOSYS - Naval E-Maintenance Oriented SYStem
    • Research contract DCNS: Direction des Constructions Navales Services, France
    • Duration: 2 years (2004–2006), Role of FEMTO-ST : PI
    • 6 French industrial and academic partners of GdR MACS, GT MACOD: FEMTO-ST/UFC, CEGELEC, CRAN, UTT
    • Scope: diagnostic, prognostic and dynamic monitoring
    • This collaboration allowed the vreation in 2007 of the spin-off e-m@systec, TEMIS incubation, Besançon